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. 2022 Sep 11;65:101598. doi: 10.1016/j.molmet.2022.101598

Figure 3.

Figure 3

MSDC-0602K improves lipidome and metabolome of circulating plasma in more extend than BM composition in comparison to pioglitazone in obese mice. Global lipidomic and metabolomic analyses of plasma samples using LC–MS. A) Venn diagram illustrating shared and uniquely detected metabolites in plasma and BM using four LC-MS platforms. B) Log2-fold change of the 32 lipid classes annotated in plasma and BM in HFD, HFD + P and HFD + M groups. (C) Heatmap of the sum of abundances of all lipid species for each lipid class for plasma with group averages (n = 9–10 per group). Lipid classes statistically altered are marked by an asterisk (∗) based on ANOVA with p(FDR) < 0.05. Differences between groups are marked as 1 (HFD vs. HFD + P; p < 0.05), 2 (HFD vs. HFD + M; p < 0.05) and 3 (HFD + P vs. HFD + M; p < 0.05). (D) Heatmap of the sum of abundances of all lipid species for each lipid class for BM with group averages. Lipid classes statistically altered are marked by an asterisk (∗) based on ANOVA with p(FDR) < 0.05 (n = 6 per group). Differences between groups are marked as 2 (HFD vs. HFD + M; p < 0.05) and 3 (HFD + P vs. HFD + M; p < 0.05). (Lipid class annotation: CAR: acylcarnitine; CE: cholesteryl ester; CL: cardiolipin; Cer, ceramide; CoQ: coenzyme Q; DG: diacylglycerol; EtherPE: ether-linked phosphatidylethanolamine; EtherLPE: ether-linked lysophosphatidylethanolamine; EtherPI: ether-linked phosphatidylinositol; EtherPC: ether-linked phosphatidylcholine; EtherTG: ether-linked triacylglycerol; FA: free fatty acid; FAHFA: fatty acid ester of hydroxy fatty acid; HexCer: hexosylceramide; LPC: lysophophatidylcholine; LPE: lysophosphatidylethanolamine; LPG: lysophosphatidylglycerol; LPI: lysophosphatidylinositol; LPS: lysophosphatidylserine; MG: monoacylglycerol; NAE: N-acyl ethanolamines; OxPE: oxidized phosphatidylethanolamine; PC: phosphatidylcholine; PE: phosphatidylethanolamine; PEtOH: phosphatidylethanol; PG: phosphatidylglycerol; PI: phosphatidylinositol; PS: phosphatidylserine; SM: sphingomyelin; SSulfate: sterol sulfate; TG: triacylglycerol).