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. 2022 Sep 16;2022:1032106. doi: 10.1155/2022/1032106

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Copyright © 2022 Hu Zongqiang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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TIMP3 is a target of miR-452-5p in HCC. (a) Venn plot showed the overlapped genes predicted by starBase and TargetScan webtools. (b) Predicted binding sequence of miR-452-5p on TIMP3. (c) A dual-luciferase reporter assay. (d) A dual-luciferase reporter assay was performed to determine the effect of exosomal miR-492-5p on the luciferase activity. (e, f) The expression of both TIMP3 mRNA and protein decreased after overexpressing miR-452-5p in THP-1 cells. (g) mRNA expression of M2 macrophage markers. (h) mRNA expression of M2 macrophage markers in THP-1 cells after different treatment. (i) Cell migration and invasion detected by Transwell assay. ^∗∗P < 0.01.