Fig. 3.

CD44 was identified as an important factor associated with LGG patient prognosis. (A) Interaction network constructed with the 7 hub genes with an interaction confidence value greater than 0.95. (B) Univariate Cox regression analysis of 7 hub genes, which showed that only 4 factors (including CD44) reached statistical significance. Univariate Cox regression analysis of 5 hub genes in the CGGAseq1 cohort (C) and CGGAseq2 cohort (D). Survival analysis of LGG patients with distinct CD44 expression (E) and SYK expression (F). Patients were grouped into high expression or low expression groups relative to the median expression level. p < 0.001 by log-rank test. Differential expression of CD44 and SYK in normal and tumour samples in the TCGA (G) and CGGA (H) databases. Only the expression of CD44 was much higher in the tumour (red) than in normal tissue (grey and green) in both cohorts, with p < 0.05. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)