Table 1.

Staging.

Stage	International Staging System (ISS)	Revised-ISS (R-ISS)
I	Serum B2M < 3.5 mg/L Serum albumin ≥3.5 g/dL	ISS stage I (left) AND standard-risk cytogenetics by FISH AND normal serum LDH
II	Not ISS stage I or III	Not R-ISS stage I or III
III	Serum B2M ≥ 5.5 mg/dL	ISS stage III (left) AND high-risk cytogenetics by FISH OR Elevated serum LDH

Abbreviations: B2M: beta-2-microglobulin, LDH: lactate dehydrogenase, FISH: fluorescence in situ hybridization.

Notes: High risk cytogenetics includes one of the following: deletion (17p), translocation (4; 14), translocation (14; 16).