Table 3.

Commonly used first-line regimens in multiple myeloma.

	Preferred	Other Recommended	Useful in Certain Circumstances
Transplant Eligible	Bortezomib, lenalidomide, dexamethasone Bortezomib, cyclophosphamide, dexamethasone	Carfilzomib, lenalidomide, dexamethasone Daratumumab, lenalidomide, bortezomib, dexamethasone Ixazomib, cyclophosphamide, dexamethasone	Bortezomib, thalidomide, dexamethasone Cyclophosphamide, lenalidomide, dexamethasone Daratumumab, cyclophosphamide, bortezomib, dexamethasone Daratumumab, bortezomib, thalidomide, dexamethasone Dexamethasone, thalidomide, cisplatin, doxorubicin, cyclophosphamide, etoposide, bortezomib
Transplant Ineligible	As above AND: Daratumumab, lenalidomide, dexamethasone Lenalidomide, dexamethasone	Carfilzomib, lenalidomide, dexamethasone Ixazomib, lenalidomide, dexamethasone Daratumumab, bortezomib, melphalan, prednisone Daratumumab, cyclophosphamide, bortezomib, dexamethasone	Bortezomib, dexamethasone Cyclophosphamide, lenalidomide, dexamethasone Carfilzomib, cyclophosphamide, dexamethasone