Table 1.

Comparison of frequency of metastases to various organs in BALB/c mice bearing negative control and a isoform knockout 4T1-12B allografts

Cell line	Spleen	Liver	Kidney/adrenal	Lungs	Heart	Brain	Limbs
PX2	3 (15)	3 (15)	2 (15)	15 (15)	0 (15)	1 (15)	15 (15)
a1 KO	0 (8)	1 (8)	0 (8)	3 (8)	0 (8)	0 (8)	8 (8)
a2 KO	1 (10)	2 (10)	1 (10)	10 (10)	0 (10)	0 (10)	10 (10)
a3 KO	0 (9)	0 (9)	0 (9)	9 (9)	0 (9)	0 (9)	9 (9)
a4.5 KO	0 (10)	0 (10)	0 (10)	0 (10)	0 (10)	0 (10)	10 (10)
a4.9 KO	0 (9)	0 (9)	0 (9)	1 (9)	0 (9)	0 (9)	9 (9)

Table shows the frequency of metastases seen in organs imaged ex vivo using the IVIS imaging system following implantation of a subunit knockout strains of 4T1-12B cells in mice as described in Experimental Procedures. Data represent the number of mice showing metastases, with the total number of mice per group shown in parentheses.