Table 1.

Extraction recovery and matrix effect of TAD and IS in rat plasma samples using sol–gel CX 20 M at the three concentration levels and assay by the developed FPSE-UPLC-ESI- MS/MS method.

QC samples	Recovery* (%)		Matrix factor*
	TAD	IS	TAD	IS	IS-normalized
LQC (0.5 ng mL -1)	97.95	98.12	0.943	0.957	0.985
MQC (10 ng mL -1)	98.76	99.55	0.972	0.980	0.992
HQC (100 ng mL -1)	99.36	100.6	0.998	0.990	1.008

*Average of five determinations.