Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Solution-phase, nucleophilic displacement of NAU-appended peptides to access unprotected C-terminally modified peptides.
| ||||||
|---|---|---|---|---|---|---|
|
| ||||||
| entry | Nuc-H | base (equiv) | solvent | ratio of | ||
| 97 | 98 | 99 | ||||
| 1 | BuNH2 | - | MeCN/H20 | 93 | - | 7 |
| 2 | BuNH2 | - | MeCN | >99 | - | - |
| 3 | aniline | Hünig’s base (5) | MeCN | 8 | 92 | - |
| 4 | MeOH | Hünig’s base (5) | MeCN | 42 | 58 | - |
| 5 | NaBH4 | - | THF/MeCN | 77 | - | 23 |
