Figure 4.

Infection with SARS-CoV-2 MA10 virus induces ADRD risk genes and complement activation in aged mice

(A) Histograms depicting mRNA fold change of ADRD risk genes (Fkbp5, Ifitm3), and complement activation genes (Cr1, C5ar1), in brains collected from MA10-infected mice. (B) Bright-field images and respective quantification showing FKBP5 expression in the olfactory bulb, cortex, and hippocampus of MA10-infected 20-month-old mice brains at 18 DPI. (C) Ingenuity Pathway Analysis (IPA) network showing genes that are differentially expressed in cortex of infected aged mice (20 months old) 18 DPI as assayed by nCounter neuroinflammatory and glial profiling panel. n = 3; data expressed as mean ± SEM; ∗ compared with respective mock; # compared with respective 4 DPI; ∗p < 0.05 by ANOVA with Holm-Sidak test.