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. 2022 Sep 24;27:217–229. doi: 10.1016/j.omtm.2022.09.007

Figure 5.

Figure 5

SARS-CoV-2 MA10 infection induces p-tau expression in olfactory bulb, cortex, and hippocampus of 6- and 20-month-old mice

(A) Bright-field images showing immunoperoxidase staining of p-tau (pT231) in olfactory bulb (top panel), cortex (middle panel), and hippocampus (bottom panel) of 3-, 6-, and 20-month-old mice at 18 DPI. Histogram showing ImgaeJ quantification of p-tau expressing cells. (B) Bright-field images showing immunoperoxidase staining of tau (T22), oligomeric expression in olfactory bulb (top panel), cortex (middle panel), and hippocampus (bottom panel) of 3-, 6- and 20-month old mice, at 18 DPI. Histogram showing ImgaeJ quantification of tau (T22)-expressing cells. (C) Co-localization of CD31-p-tau expression in olfactory bulb, cortex, and hippocampus. CD31: red, DAPI: blue, and p-tau: green. Arrows indicate areas of p-tau/CD31 co-localization. n = 3; data expressed as mean ± SEM; ∗ compared with respective mock; # compared between 6- and 20-month-old infected mice, ∗,#p < 0.05.