Table 1.
General characteristics of patients with HIV and concomitant CRC according to antiviral regimens (n = 66)
| Demographic characteristics | DTG/3TC/TDF (group I) n = 20 | DTG/ABT (group II) n = 24 | BIC/TAF/FTC (group III) n = 22 |
|---|---|---|---|
| Sex | |||
| Male | 13 | 18 | 8 |
| Female | 7 | 6 | 14 |
| Age (yeras) | 61.5 (44–74) | 60.04 (45–85) | 54.27 (33–74) |
| BMI (kg/m2) | 23.37 (18.37–28.23) | 22.74 (17.97–26.81) | 23.73 (18.03–25.30) |
| TNM stage | |||
| II | 14 | 10 | 18 |
| III | 6 | 14 | 4 |
| Differentiation | |||
| Well differentiated | 0 | 3 | 2 |
| Moderately differentiated | 15 | 14 | 16 |
| Poorly differentiated | 5 | 7 | 4 |
| Baseline CD4 count (cells/ul) | 368.35 (195–980) | 272.71 (83–757) | 315.14 (85–980) |
| CD4/CD8 ratio | 0.91 (0.19–2.87) | 0.75 (0.14–2.86) | 0.60 (0.08–1.68) |
| Type of cancer | |||
| Rectal | 6 | 11 | 4 |
| Colon | 14 | 13 | 18 |
| Comorbidities | |||
| Hypertension | 2 | 1 | 2 |
| Diabetes mellitus | 4 | 1 | 3 |
| HBV | 1 | 1 | 1 |
| HCV | 1 | 2 | 0 |
| Type of surgery | |||
| Right hemicolectomy | 3 | 9 | 6 |
| Left hemicolectomy | 5 | 1 | 4 |
| Sigmoidectomy | 6 | 3 | 8 |
| Low anterior resection | 6 | 11 | 4 |
| Baseline HIV viral load (copies/ml) | |||
| ≤ 20 | 18 | 19 | 17 |
| 20–1000 | 1 | 1 | 2 |
| > 1000 | 1 | 4 | 3 |
| Chemotherapy regimen | |||
| CapeOX | 16 | 19 | 22 |
| mFolfox6 | 4 | 5 | 0 |
| Untreated patients | 1 | 4 | 3 |
| Pretreated patients | 19 | 20 | 19 |
CRC = Colorectal cancer
DTG/3TC/TDF = dolutegravir/lamivudine/tenofovir
DTG/ABT = dolutegravir/albuvirtide
BIC/TAF/FTC = bictegravir/tenofovir alafenamide/emtricitabine
BMI = Body Mass Index
TNM stage was according to the AJCC 8th classification