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. 2022 Sep 24;12:160. doi: 10.1186/s13578-022-00896-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Telomere content and telomere restriction fragment analysis in TMM subgroups. A Telomere content (TC) calculated from WGS data, displayed as tumor/normal ratio, in telomere maintenance defined subgroups. Mean telomere content: TMM^[−], 0.87; ALT^[+], 6.39; TEL^[+], 0.96. Kruskal–Wallis test and Dunn’s multiple comparison test were used for statistical analysis; ambiguous cases were excluded. Whiskers are limited to 1.5 × interquartile range. B Telomere restriction fragment (TRF) analysis, displayed in kilobase pairs (kbp), in telomere maintenance defined subgroups. Mean telomere length: TMM^[−], 8.39; ALT^[+], 10.66; TEL^[+], 6.36. Kruskal–Wallis test and Dunn’s multiple comparison test were used for statistical analysis; ambiguous cases were excluded. Whiskers are limited to 1.5 × interquartile range. C Correlation analysis of TRF and TC in neuroblastoma samples (n = 36). Ambiguous cases were excluded from calculation of Pearson correlation