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. 2022 Sep 24;12:160. doi: 10.1186/s13578-022-00896-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Association of TERRA expression and other ALT associated characteristics. A Normalized TERRA read count in telomere maintenance defined subgroups. Mean TERRA read count: TMM^[−], 0.004; ALT^[+], 0.011; TEL^[+], 0.002. Kruskal–Wallis test and Dunn’s multiple comparison test were used for statistical analysis; ambiguous cases were excluded. Whiskers are limited to 1.5 × interquartile range. B Correlation analysis of normalized TERRA read count and C-circle signal intensity. C Correlation analysis of TC, displayed as tumor/normal ratio, and normalized TERRA read count. D Correlation analysis of TRF, displayed in kilobase pairs (kbp), and normalized TERRA read count. Correlation coefficients were calculated according to Pearson; ambiguous cases were excluded from calculations