Table 3.
Multivariate analysis of OS
| Parameter | median OS (m) | HR | 95%CI | P |
|---|---|---|---|---|
| Sex | 0.111 | |||
| Female | - | 1.000 | ||
| Male | 33.3 | 1.976 | 0.856–4.558 | |
| Smoking history | 0.696 | |||
| N0 | 39.8 | 1.000 | ||
| Yes | 27.9 | 1.154 | 0.562–2.369 | |
| Tumor histology | 0.175 | |||
| SCC | 21.3 | 1.000 | ||
| Adenocarcinoma | 36.3 | 0.612 | 0.301–1.244 | |
| Thoracic operation | 0.966 | |||
| Yes | 39.8 | 1.000 | ||
| No | 28.9 | 1.013 | 0.562–1.825 | |
| Neurologic symptoms | 0.002 | |||
| No | 76.4 | 1.000 | ||
| Yes | 21.3 | 2.462 | 1.401–4.326 | |
| BMsize, Dmax(cm) | 0.189 | |||
| ≤ 3 | 36.4 | 1.000 | ||
| > 3 | 18.4 | 1.555 | 0.805–3.004 | |
| EMs | 0.581 | |||
| No | 36.4 | 1.000 | ||
| Yes | 28.9 | 1.190 | 0.642–2.207 | |
| RPA class | 0.010 | |||
| 1 | 76.4 | 1.000 | ||
| 2 | 24.0 | 2.918 | 1.294–6.579 |
Abbreviations: BMs brain metastases, EMs extracranial metastases, GPA graded prognostic assessment, HR hazard ratio, LINAC-SRS stereotactic radiotherapy using linear accelerators, KPS Kanofsky Performance Scale, RPA recursive partitioning analysis, SCC squamous cell carcinoma, TT targeted therapy, WBRT whole-brain radiotherapy, WBRT + RTB whole-brain radiotherapy plus radiotherapy boost