Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 17;50(17):9663–9674. doi: 10.1093/nar/gkac792

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 2. — Active site view of Kod-RI TNA polymerase showing pTNA incorporation. (A) Schematic representation of the crystallized binary complex following the addition and translocation of two adenosine nucleotides. (B) View of the active site of Kod-RI incorporating pTNA with a 2F_o–F_c composite polder map contoured at 7.5σ for the incorporated ptA12 and ptA13, and another polder map contoured at 5.0σ for both conformations of arginine 606, labeled A and B. The exonuclease domain is hidden to avoid obstruction of the view. (C) Kod-RI incorporating DNA with polder maps contoured at 7σ for DNA (dA12 and dA13) and 4σ for the single conformation of arginine 606. (D, E) The intermolecular interactions observed in the active site with distances reported in angstroms. Color scheme: structure obtained for the pTNA extended primer (green) and DNA extended primer (yellow).