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. 2022 Sep 12;50(17):9765–9779. doi: 10.1093/nar/gkac735

Figure 5.

Figure 5.

(A) Preparation of HepG2 cells that co-overexpressed c-JUN and YAP1 by lentivirus gene transfer. Expression levels of c-JUN, YAP1 and YAP1(S127A) mRNAs. (B) RT-qPCR analysis of AREG and THBS1, and mitochondria-related genes. n = 3, data are represented as mean ± SD; **P < 0.01, *P< 0.05. (C) Coexistence of active marks (H3K4me1 and H3K27ac), c-JUN and YAP1/TEAD1 in the proximal and distal enhancers of THBS1 gene. ChIP-seq data are from GSM1700784 for c-JUN, GSM1614029 for YAP1 and GSM1667161 for TEAD1.