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. 2022 Sep 3;3(5):zqac043. doi: 10.1093/function/zqac043

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© The Author(s) 2022. Published by Oxford University Press on behalf of American Physiological Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — MTS mimetic induces pathological H₂O₂ mediated dilation, while NLS mimetic restores physiological NO-mediated dilation. (A) Treatment of vessels from non-CAD subjects with the TERT MTS mimetic peptide induces a CAD like phenotype for FMD (Peg-catalase inhibitable), (B) while treatment with TERT NLS mimetic has no effect. (C) Treatment of vessels from subjects with CAD with TERT NLS mimetic is sufficient to restore FMD to NO (L-NAME mediated). (D) Endothlial indepedent dilation to papaverine was not alterd in any groups. * P < 0.05 2-way ANOVA RM, N = 6–11.