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. 2022 Jun 18;50(17):e100. doi: 10.1093/nar/gkac521

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Co-localization of BRD4 with different epigenetic modifications and inhibition by JQ1. (A) Co-localization of BRD4 with H3K9me3, H3K27me3, H3K36me3 or H3K9/14ac marks. Co-localization was measured in HeLaP4 cells. (B) Co-localization of BRD4 with H3K9/14ac in the presence of an increasing JQ1 concentration: 0, 25, 50, 125, 250 and 500 nM. Statistical analysis was performed by a one-way ANOVA: (ns) non-significant; **P-value < 0.01; ***P-value < 0.001; number of cells (n) = 50 with each grey dot representing one cell and two different samples analyzed per condition. Co-localization analysis was performed on Z-stacks of expanded cells consisting of 9–11 Z-slices with a Z-step size of 0.2 μm.