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. Author manuscript; available in PMC: 2022 Sep 24.
Published in final edited form as: Curr Protoc Microbiol. 2020 Dec;59(1):e119. doi: 10.1002/cpmc.119

Table 1.

Interpretation for the Percent Resistance After ExoV Digestion and Copy Number Ratio Analyses

HPV genome state Percent resistance of HPV E6 DNA after ExoV digestion Ratio of E2/E6, E5/E6, or L2/E6 (not treated with ExoV)
Defective episome (plasmid contaminant) >20% <0.5 for at least 1 ratio
Intact episome >20% ~1 for all ratios (range 0.8–1.2)
Integrated type I <10% <0.5 for at least 1 ratio
Integrated type II <10% ~1 for all ratios (range 0.8–1.2)

ExoV, exonuclease V; HPV, human papillomavirus.