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. 2022 Aug 25;135(14):1716–1727. doi: 10.1097/CM9.0000000000002294

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Microbial function prediction, inner associations, and correlation of microbiota with clinical parameters. (A) Significant level 2 pathways in IBSN and IBSP in comparison with HC. Y-axis: the number or level 3 pathways belonging to level 2; (B) Comparison of the bacterial invasion of epithelial cells pathway in the three groups (^∗P < 0.05), (C) Associations among different genus in HC, IBSN, or IBSP; (D) Correlation of significant changing microbiota in IBSN and IBSP with clinical and experimental parameters: (^∗P < 0.05; ^†P < 0.01). HC: Healthy control; IBS: irritable bowel syndrome; IBSP: breath test positive IBS patients; IBSN: breath test negative IBS patients; RA: Relative abundance.