Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 9;13:966417. doi: 10.3389/fimmu.2022.966417

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Shahi, Ghimire, Lehman and Mangalam

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

HFD induced obesity causes change in gut microbiota in HLA-DR3 transgenic mice. Amplicon based microbial diversity of mice on a prediet (n=9), a high fat diet (HFD, n=5) or normal chow (NC, n=5). Alpha diversity measures obtained using (A) Observed taxa, (B) Shannon diversity. PCOA plot representing beta diversity index measured using (C) Bray-curtis dissimilarity metrics, (D) Weighted unifrac measures among the groups. (E) Bar plot representing significantly altered taxa between HFD and NC, and (F) HFD and prediet conditions following lefse analysis in R among all taxonomic ranks with lda_cutoff of 2 and wilcoxon_cutoff of 0.01, and kw_cutoff of 0.01 respectively. Kruskal wallis (KW) test was performed for (A–C) followed by pairwise comparison using wilcox test and p-value with Benjamini Hochberg (BH) correction. adonis test was performed for (D, E).