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. 2022 Sep 9;13:966417. doi: 10.3389/fimmu.2022.966417

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Copyright © 2022 Shahi, Ghimire, Lehman and Mangalam

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A High Fat Diet results in increase pro-inflammatory cytokines. (A) Schematic of experimental design. 6-8-week old HLA-DR3 transgenic male mice were placed on the indicated diet and after 5 weeks sera were collected from blood. MCP-1a concentrations post diet (B), CCL-11 concentrations post diet (C), CXCL-5 concentrations post diet (D). Error bars represent the standard error of the mean for each experimental group. p-value was determined by 2way ANOVA Sidak multiple comparisons test for (B–D).