Table 1.
basic characteristics of the included studies.
| Id | Region | Design | Center | Study time | Subject | Mean age | Male (%) | BMI (kg/m2) | ALT (U/L) | Etiology | Scoring system | Length of biopsy samples | QUADAS scores |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Leung [17] | China | Prospective | Single center | 2011-2012 | 226 | 48.8 | 65 | 24.2 (21.6-27.3)† | 69 (37.5-105)† | HBV | Metavir | ≥15 mm | 12 |
| Yao [22] | China | Prospective | Single center | 2013-2015 | 54 | 36.7 | 76 | 23.9 (21.9-25)† | 50.4 (28.8-129.2)† | HBV | Ishak | ≥20 mm | 14 |
| Zeng [18] | China | Prospective | Single center | 2013-2015 | 257 | 36.7 | 77.4 | 21.7 (19.7-23.9)† | 42 (28.3-67.8)† | HBV | Metavir | ≥15 mm | 13 |
| Ferraioli [21] | Italy | Retrospective | Single center | 2010-2012 | 121 | 44.8 | 71.9 | 25.4 (17.1-39)§ | 75 (40-126)† | HCV | Metavir | ≥10 mm | 14 |
| Deffieux [11] | France | Prospective | Single center | 2011-2012 | 70 | 46.8 | 79 | 24.1 (16.7-35.9)§ | 81.3 (15-260)§ | HBV (n = 24)HCV (n = 46) | Metavir | ≥9 mm | 14 |
| Xia 2019 | China | Prospective | Single center | 2017 | 158 | 38.55 | 60.1 | NA | NA | HBV | Scheuer | ≥15 mm | 12 |
| Paul [23] | India | Prospective | Single center | 2012-2014 | 240 | 32.6 | 73.3 | 22.3 ± 4.1 | 71.7 ± 89.0 | HBV (n = 172) HCV (n = 68) | Metavir | ≥10 mm | 12 |
| Osman [24] | Egypt | Prospective | Single center | 2019 | 180 | 51.07 | 65 | NA | NA | HBV (n = 32) HCV (n = 148) | Metavir | NA | 13 |
∗Mean ± SD. †Median (interquartile range). §Median (range). BMI: body mass index; NA: not available; QUADAS: quality assessment of studies of diagnostic accuracy studies; TE: transient elastography.