Table 4.
Meta-analysis of studies with head-to-head comparison of TE and 2D-SWE in staging fibrosis.
| Methods | No. of studies (no. of patients) | Cutoff values range | Sensitivity (95% CI) | Specificity (95% CI) | PLR (95% CI) | NLR (95% CI) | AUROC(95% CI) | DOR (95% CI) |
|---|---|---|---|---|---|---|---|---|
| Staging fibrosis stage F ≥ 2 | ||||||||
| TE | 8 (1301) | 6.1-11.8 | 0.78 (0.72-0.84) | 0.79 (0.71-0.86) | 3.71 (2.43-5.67) | 0.28 (0.21-0.38) | 0.85 (0.82-0.88) | 14.12 (7.88-25.31) |
| 2D-SWE | 8 (1301) | 6-9.58 | 0.84 (0.78-0.88) | 0.84 (0.77-0.88) | 4.87 (3.22-7.36) | 0.2 (0.13-0.32) | 0.90 (0.88-0.93) | 25.19 (11.47-55.32) |
| Staging fibrosis stage F ≥ 3 | ||||||||
| TE | 6 (1089) | 8-8.6 | 0.85 (0.81-0.89) | 0.88 (0.81-0.93) | 7.05 (4.04-12.32) | 0.17 (0.12-0.24) | 0.91 (0.88-0.93) | 44.23 (20.5-95.43) |
| 2D-SWE | 6 (1089) | 7-9.1 | 0.88 (0.82-0.92) | 0.85 (0.77-0.91) | 6.19 (371-10.30) | 0.14 (0.08-0.23) | 0.93 (0.90-0.95) | 50.24 (21.09-119.69) |
| Staging fibrosis stage F = 4 | ||||||||
| TE | 6 (1089) | 11.2-14.6 | 0.90 (0.83-0.94) | 0.91 (0.84-0.95) | 10.7 (5.46-20.99) | 0.11 (0.05-0.24) | 0.95 (0.93-0.97) | 110.24 (40.75-298.24) |
| 2D-SWE | 6 (1089) | 9.7-11.3 | 0.95 (0.85-0.99) | 0.91 (0.86-0.95) | 9.34 (5.91-14.76) | 0.07 (0.02-0.27) | 0.97 (0.95-0.98) | 155.43 (63-383.43) |
2D-SWE: two-dimensional shear wave elastography; AUROC: area under summary receiver operating characteristic; CI: confidence interval; DOR: diagnostic odds ratio; NLR: negative likelihood ratio; PLR: positive likelihood ratio; TE: transient elastography.