Table 1.
Characteristics of the BDR samples profiled in this study
| Analysis | Sample type | N | Age (years) | Sex | Neuropathology | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Braak NFT stage | CERAD score | Thal phase | LB stage | TDP-43 status | ||||||||||||
| Median (IQR) | Age range | Female | Male | N | Mean (SD) | N | Mean (SD) | N | Mean (SD) | N | Mean (SD) | N | Cases (%) | |||
| Bulk Cortex EWAS | Bulk cortex | 631 | 84 (78–90) | 41–104 | 296 | 335 | 618 | 3.72 (1.90) | 572 | 1.69 (1.28) | 558 | 3.09 (1.78) | 538 | 1.34 (2.26) | 590 | 127 (22) |
| Analysis of purified nuclei populations | Total nuclei | 26 | 80.5 (74–85.75) | 61–101 | 14 | 12 | 26 | 3.12 (2.47) | 24 | 1.46 (1.47) | 24 | 2.42 (1.90) | 22 | 0.723 (1.72) | 24 | 4 (17) |
| NeuN+ | 27 | 81 (74–85.5) | 61–101 | 15 | 12 | 27 | 3.04 (2.46) | 25 | 1.4 (1.47) | 25 | 2.32 (1.93) | 23 | 0.696 (1.69) | 25 | 4 (16) | |
| SOX10+ | 28 | 80.5 (74–85.25) | 61–101 | 15 | 13 | 28 | 3.00 (2.41) | 26 | 1.35 (1.47) | 24 | 2.23 (1.95) | 24 | 0.791 (1.72) | 26 | 4 (15) | |
| NeuN–/SOX10– | 21 | 81 (74–85) | 61–101 | 13 | 8 | 21 | 3.19 (2.6) | 19 | 1.53 (1.47) | 19 | 2.47 (1.98) | 17 | 0.94 (1.92) | 20 | 3 (15) | |
| Cell-deconvolution reference | NeuN+ | 12 | 81 (77.25–90.25) | 55–95 | 5 | 7 | 11 | 2.72 (1.74) | 10 | 1 (0.41) | 10 | 1.6 (0.97) | 10 | 0.4 (1.26) | 11 | 0 |
| SOX10+ | 12 | 81 (77.25–90.25) | 55–95 | 5 | 7 | 11 | 2.72 (1.74) | 10 | 1 (0.41) | 10 | 1.6 (0.97) | 10 | 0.4 (1.26) | 11 | 0 | |
| NeuN–/SOX10– | 12 | 81 (77.25–90.25) | 55–95 | 5 | 7 | 11 | 2.72 (1.74) | 10 | 1 (0.41) | 10 | 1.6 (0.97) | 10 | 0.4 (1.26) | 11 | 0 | |
IQR interquartile range, SD standard deviation.