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. 2022 Sep 24;13:5606. doi: 10.1038/s41467-022-33067-5

Fig. 3. SAT Tregs decrease acutely following a hypercaloric, high-fat diet and are related to adipocyte MHCII gene expression and insulin resistance.

Fig. 3

a Clinical Characteristics of lean subjects (N = 11) before and after 2 weeks of a hypercaloric, high saturated fat diet (HFD). Change in SAT Tregs as % of total CD4 + cells in the stromal vascular fraction (SVF) from before to after 2 weeks HFD (N = 11) by Wilcoxon signed ranks test (b) as a group and (c) in each individual participant. d Correlation (Spearman) between the change in M value (N = 11) and decrease in SAT Tregs as percent (%) of total CD4 + cells in the SVF from before to after 2 weeks post HFD. Correlations were two-sided without correction for multiple comparisons. e SAT adipocyte gene expression of MHCII-related genes, STAT1, and adipokines/cytokines from before to after 2 weeks post HFD. See text for abbreviations. Data were analyzed by two-sided independent sample T-test (without adjustment for multiple comparisons). Source data are provided as a Source Data file. Data presented as mean ± SEM. ***p < 0.001; **p < 0.01; *p < 0.05; and †p < 0.10. No replicate samples were utilized.