Table 2.
The seven genetic variants significantly associated with circulating CC16 levels§ among 289 EPIC participants after FDR adjustment and LD-based pruning.
| Position | rs ID | Alt. Allele | Ref. Allele | MAF^ | Gene | Coef. (95% CI)* | P | FDR | R-squared |
|---|---|---|---|---|---|---|---|---|---|
| 62186542 | rs3741240 | A | G | 0.335 | SCGB1A1 | −0.634 (−0.778, −0.490) | 6.2 × 10−18 | 4.3 × 10−16 | 0.190 |
| 62197427 | rs2077224 | A | C | 0.357 | AHNAK | 0.315 (0.158, 0.471) | 8.3 × 10−5 | 0.002 | 0.048 |
| 62190700 | rs2302364 | C | T | 0.172 | SCGB1A1 | −0.411 (−0.616, −0.205) | 8.9 × 10−5 | 0.002 | 0.046 |
| 34937697 | rs2016814 | C | T | 0.203 | PDHX, APIP | −0.281 (−0.458, −0.104) | 0.002 | 0.022 | 0.028 |
| 34909926 | rs1571133 | G | T | 0.323 | APIP | −0.234 (−0.394, −0.074) | 0.004 | 0.031 | 0.023 |
| 34842506 | rs568529 | A | C | 0.295 | -- | −0.233 (−0.405, −0.060) | 0.008 | 0.038 | 0.019 |
| 34780278 | rs906902 | A | G | 0.393 | -- | −0.207 (−0.363, −0.051) | 0.009 | 0.039 | 0.016 |
§
Standardized levels of log-transformed CC16 were used in analyses
^
MAF: minor allele frequency
*
The coefficient indicates the change in SDs of CC16 levels associated with one-allele change of the specific genetic variant from additive models.