Table 3.

Estimated effects of the 7 pQTL SNVs on changes in FEV₁ and FEV₁/FVC % predicted between ages 7–16 years. Models include 611 NHW EPIC participants recruited under Criterion 1 with 20,801 lung function measurements.

	rs ID	Estimated effects on FEV1 % predicted change between ages 7–16 yrs *		Estimated effects on FEV1/FVC % predicted change between ages 7–16 yrs *
		Coefficient (95% CI)	p	Coefficient (95% CI)	p
62186542	rs3741240
GG		Ref		Ref
A/G		−0.08 (−0.40, 0.24)	0.611	−0.10 (−0.28, 0.08)	0.285
AA		−0.57 (−1.07, −0.07)	0.025	−0.42 (−0.70, −0.14)	0.003
62197427	rs2077224
CC		Ref		Ref
A/C		−0.06 (−0.38, 0.27)	0.735	0.12 (−0.06, 0.30)	0.200
AA		0.05 (−0.46, 0.55)	0.853	0.05 (−0.23, 0.33)	0.735
62190700	rs2302364
TT		Ref		Ref
C/T		−0.31 (−0.64, 0.02)	0.067	−0.17 (−0.36, 0.01)	0.067
CC		−0.60 (−1.69, 0.50)	0.285	−0.65 (−1.25, −0.04)	0.037
34937697	rs2016814
TT		Ref		Ref
C/T		0.37 (−0.41, 1.15)	0.354	−0.18 (−0.61, 0.26)	0.419
CC		0.39 (−0.37, 1.15)	0.312	−0.28 (−0.70, 0.14)	0.187
34909926	rs1571133
TT		Ref		Ref
G/T		0.72 (0.22, 1.23)	0.005	0.03 (−0.26, 0.31)	0.846
GG		0.67 (0.17, 1.17)	0.009	−0.12 (−0.40, 0.16)	0.410
34842506	rs568529
CC		Ref		Ref
A/C		−0.03 (−0.60, 0.54)	0.924	−0.14 (−0.46, 0.18)	0.386
AA		0.13 (−0.43, 0.69)	0.650	−0.04 (−0.36, 0.27)	0.787
34780278	rs906902
GG		Ref		Ref
A/G		0.17 (−0.17, 0.50)	0.330	0.19 (0.004, 0.38)	0.046
AA		0.28 (−0.18, 0.74)	0.231	0.02 (−0.23, 0.28)	0.859

^*Models adjusted for sex, age at lung function measurement, CFTR genotype risk group, maternal smoking during pregnancy, and annual household income.

Associations significant after FDR adjustment are reported in bold font. The FDR significance level is 0.0033.