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. Author manuscript; available in PMC: 2023 Sep 21.
Published in final edited form as: Neuron. 2022 Jun 30;110(18):2902–2915. doi: 10.1016/j.neuron.2022.06.004

Figure 3. Dynamic 3D genome re-organization during development and in response to stimulation in neurons.

Figure 3.

(A) Features of 3D genome re-organization during embryonic stem cell – neural progenitor – neuron/glia differentiation.

(B) Dynamic chromatin looping in response to neuronal activation, a model of signal integration for immediate early gene (IEG) and secondary response genes (SRG).

(C) A potential model for multiple inputs/activity-inducible enhancers to regulate the same downstream gene. Invariant and activity-induced loops form the hub and enable multiple enhancers to contact and regulate the same downstream gene. This process may precede transcriptional activation.

(D) A model of epigenetic priming during sequential phases of learning and memory.