Table 1.

Participant and eye characteristics of the study populations at baseline.

	AREDS, by person	AREDS, by eye	AREDS2, by person	AREDS2, by eye
Participants/eyes	3182 participants	6959 eyes of 3780 participants	1259 participants	3355 eyes of 2056 participants
Mean age (years), mean (SD)	69.0 (5.0)	69.4 (5.1)	71.0 (7.9)	72.3 (7.9)
Female	57.2%	56.3%	57.8%	55.4%
Race
White	94.9%	95.5%	95.0%	95.2%
Non-white	5.1%	4.5%	4.8%	4.7%
Smoking status
Never	47.5%	45.0%	48.7%	45.8%
Former	46.2%	47.4%	45.7%	48.2%
Current	6.3%	7.6%	5.6%	6.0%
Body mass index			-	-
≤25	33.8%	33.0%
26–30	41.8%	41.6%
>30	24.4%	25.3%
RPD presence at baseline*	7.4%†	5.3%	9.0%†	11.4%
AMD severity at baseline‡	0: 43.7%	1: 41.6%	0: 0.2%	1: 0.7%
	1: 22.3%	2: 14.6%	1: 2.3%	2: 1.4%
	2: 15.4%	3–4: 14.5%	2: 23.1%	3–4: 8.5%
	3: 10.3%	5–6: 13.3%	3: 24.1%	5–6: 37.5%
	4: 8.4%	7–8: 16.1%	4: 50.3%	7–8: 51.9%
Follow-up time (years), mean (SD)	9.0 (2.9)	8.8 (2.9)	4.8 (0.8)	4.8 (0.8)

^*by deep learning-based automated grading of color fundus photographs (AREDS) or by reading center grading of fundus autofluorescence images (AREDS2)

^†for person-based analyses, defined as present if present in either eye

^‡according to modified Simplified Severity Scale (levels 0–4), by person, or 9-step Severity Scale (levels 1–9), by eye

Abbreviations: AMD=age-related macular degeneration; AREDS=Age-Related Eye Disease Study; RPD=reticular pseudodrusen; SD=standard deviation