Table 2.

Progression to late age-related macular degeneration and its subtypes in the Age-Related Eye Disease Study, by person: hazard ratios associated with reticular pseudodrusen presence, separately according to different levels on the modified Simplified Severity Scale.

	Late AMD		Geographic atrophy		Neovascular AMD
Modified Simplified Severity Scale level	Hazard ratio associated with RPD presence (95% CI)	P value	Hazard ratio associated with RPD presence (95% CI)	P value	Hazard ratio associated with RPD presence (95% CI)	P value
0–1	3.23 (1.60–6.51)	0.001	3.47 (1.47–8.17)	0.004	2.96 (1.03–8.46)	0.043
2	3.81 (2.38–6.10)	<0.0001	4.97 (2.95–8.39)	<0.0001	3.03 (1.65–5.57)	0.0004
3	2.28 (1.59–3.27)	<0.0001	3.08 (2.10–4.54)	<0.0001	1.13 (0.68–1.88)	0.64
4	1.64 (1.20–2.24)	0.002	1.91 (1.39–2.65)	<0.0001	0.96 (0.62–1.51)	0.87

Abbreviations: AMD=age-related macular degeneration; CI=confidence interval; RPD=reticular pseudodrusen