. Author manuscript; available in PMC: 2023 Oct 1.

Published in final edited form as: Ophthalmology. 2022 May 31;129(10):1107–1119. doi: 10.1016/j.ophtha.2022.05.021

Table 3.

Progression to late age-related macular degeneration and its subtypes in the Age-Related Eye Disease Study, by eye: hazard ratios associated with reticular pseudodrusen presence, separately according to different levels on the 9-step Severity Scale.

	Late AMD		Geographic atrophy		Neovascular AMD
9-step Severity Scale levels	Hazard ratio associated with RPD presence (95% CI)	P value	Hazard ratio associated with RPD presence (95% CI)	P value	Hazard ratio associated with RPD presence (95% CI)	P value
1–6	5.11 (3.93–6.66)	<0.0001	5.90 (4.19–8.32)	<0.0001	3.73 (2.64–5.27)	<0.0001
7–8	1.78 (1.43–2.22)	<0.0001	1.86 (1.45–2.40)	<0.0001	1.05 (0.77–1.43)	0.76

Abbreviations: AMD=age-related macular degeneration; CI=confidence interval; RPD=reticular pseudodrusen