Key resources table

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
HRP-conjugated anti-rabbit IgG antibodies at 1:10000	Kiessling lab; Jackson ImmunoResearch Laboratories	#111-035-003
HRP-conjugated anti-rabbit IgG antibodies at 1:2500	Eisinger lab; Cell Signaling Technology [CST]	#7074
anti-Yap1 primary antibodies	Cell Signaling Technology [CST]	#14074, #4912
Alexa Fluor 488-conjugated secondary antibodies	Thermo Fisher Scientific	#A-11008
Bacterial and virus strains
Biological samples
Chemicals, peptides, and recombinant proteins
BRD-K43796186 (NB4A)	MuseChem	cat. #M189943
BRD-K43796186 (NB4A)	Ambinter	cat # Amb2554311
8xGTIIC-luciferase	Gift from Stefano Piccolo, Addgene	plasmid # 34615
Critical commercial assays
Deposited data
RNA-sequencing data	this paper	GSE198909
Compound Dataset	Bray et al., 2017	DOI: 10.1093/gigascience/giw014
Gene Overexpression Dataset	Rohban et al., 2017	DOI:10.7554/eLife.24060
Experimental models: Cell lines
RT112/84	Cancer Cell Line Encyclopedia (Broad Institute, Cambridge, MA)
HEK293T	ATCC
Murine KP230	Eisinger lab
STS-109 UPS	Rebecca Gladdy, MD (University of Toronto)
TC32	Patrick Grohar, MD, PhD (Children’s Hospital of Philadelphia)
HT-1080	ATCC
HCT-116	ATCC
Experimental models: Organisms/strains
Oligonucleotides
Recombinant DNA
Knockdown of YAP1 in HCT-116 cells	Dharmacon	TRCN0000107266 and TRCN0000107267
Software and algorithms
GitHub Repository to reproduce the results	this paper	DOI 10.5281/zenodo.6970733
Other