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. Author manuscript; available in PMC: 2023 Sep 21.
Published in final edited form as: Neuron. 2022 Jul 25;110(18):2929–2948.e8. doi: 10.1016/j.neuron.2022.06.021

Figure 5. Shared versus cell-type-specific pathways associated with tau pathology.

Figure 5.

(A) Overview of strategy to identify shared and cell-type-specific pathways overrepresented in the five clusters with highest cell numbers and NFT proportions.

(B) Manhattan plots of GO biological processes enriched in NFT-bearing vs. NFT-free neurons for each cluster, obtained using g:Profiler. Colored circles represent significant terms (thresholds: g:SCS significance < 0.001; GO terms with > 50 or < 500 genes; capped at terms with a −log10 [Padj] > 16). Top 5 nonredundant terms are highlighted.

(C) Functional enrichment map. Nodes represent gene sets of GO biological processes; each node is color-coded by cluster to illustrate shared and cell-type-specific contributions. Yellow circles delineate constellations of functionally related gene sets.

See also Table S4.