Table 5.

Subgroup analysis for the effect of APTT on 4-year mortality in study patients before PSM.

Characteristics	N (%)	APTT ≥ 44		P value for interaction
		HR (95% CI)	P value
Age				0.084
≤75	1911 (70.62)	2.34 (1.76-3.11)	<0.001
>75	795 (29.38)	1.67 (1.29-2.17)	<0.001
Gender				0.990
Female	717 (26.50)	2.22 (1.59-3.08)	<0.001
Male	1989 (73.50)	2.22 (1.75-2.82)	<0.001
Hypertension				0.997
No	754 (27.86)	2.23 (1.62-3.07)	<0.001
Yes	1952 (72.14)	2.27 (1.78-2.88)	<0.001
DM				0.620
No	1696 (62.68)	2.24 (1.75-2.86)	<0.001
Yes	1010 (37.32)	2.49 (1.83-3.4)	<0.001
Peripheral vascular disease				0.486
No	2351 (86.88)	2.17 (1.74-2.69)	<0.001
Yes	355 (13.12)	2.55 (1.69-3.85)	<0.001
MI				0.142
No	2195 (81.12)	2.11 (1.69-2.62)	<0.001
Yes	511 (18.88)	2.96 (1.97-4.45)	<0.001
CHF				0.019
No	2029 (74.98)	2.48 (1.91-3.23)	<0.001
Yes	677 (25.02)	1.56 (1.18-2.06)	0.002
Chronic pulmonary disease				0.076
No	2350 (86.84)	2.45 (1.98-3.03)	<0.001
Yes	356 (13.16)	1.58 (1.02-2.44)	0.042
Renal failure				0.239
No	2504 (92.54)	2.1 (1.7-2.59)	<0.001
Yes	202 (7.46)	2.82 (1.76-4.53)	<0.001
Liver disease				0.561
No	2667 (98.56)	2.25 (1.86-2.74)	<0.001
Yes	39 (1.44)	3.35 (0.98-11.5)	0.054
Obesity				0.064
No	2582 (95.42)	2.2 (1.81-2.68)	<0.001
Yes	124 (4.58)	6.17 (2.07-18.36)	0.001
Mechanical ventilation				0.981
No	96 (3.55)	2.29 (0.96-5.44)	0.060
Yes	2610 (96.45)	2.29 (1.88-2.78)	<0.001
CRRT				0.318
No	2661 (98.34)	2.1 (1.71-2.57)	<0.001
Yes	45 (1.66)	1.27 (0.66-2.44)	0.466
Vasopressor use				0.204
No	364 (13.45)	1.65 (0.95-2.87)	0.075
Yes	2342 (86.55)	2.4 (1.96-2.95)	<0.001
SOFA				0.479
≤7	2354 (86.99)	2.01 (1.6-2.53)	<0.001
>7	352 (13.01)	2.29 (1.59-3.31)	<0.001
SAPS II				0.257
≤47	2371 (87.62)	2.08 (1.67-2.6)	<0.001
>47	335 (12.38)	2.63 (1.78-3.88)	<0.001