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. 2022 Sep 24;14:110. doi: 10.1186/s13073-022-01112-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Replication of molecular signatures. A, B Comparison of log fold change of DEGs in remission (A) and non-remission (B) patients at weeks 2 (light blue) and 6 (dark blue) between discovery and replication cohorts. C Comparison of DEG-DMP correlation between discovery and replication cohorts. Gray dots represent a significant correlation in the discovery cohort while black dots significant correlation in both cohorts. D Heatmap showing Z_summary scores of baseline co-expression modules from the discovery cohort in remission (green) and non-remission (blue) samples at weeks 2 and 6 of the replication cohort. E Comparison of Z_summary scores of differentially preserved modules in discovery cohort between remission and non-remission samples at weeks 2 (circle) and 6 (triangle) in the discovery (orange) and replication (green) cohorts