Table 1.
Receptors interacting with apoE | CNS cell-type |
---|---|
SORLA (SORL1, LR11) | Microglia [154], Neurons [155, 156] |
VLDLR | Astrocytes, microglia, oligodendrocytes, pyramidal neurons, neuroblasts, glioblasts, Cajal-Retzius cells [123] |
ApoER2 (LRP8) | Granule cells of dentate gyrus, piramidal cells [123] |
LDLR | Astrocytes, neurons, oligodendrocytes [157, 158] |
LRP1 | Neurons, astrocytes, microglia, [159, 160] |
LRP2 (Megalin) | Oligodendrocytes [161], astrocytes [162], neurons [163] |
LRP4 (MEGF7) | Astrocytes, oligodendrocytes, microglia [164], neurons [165] |
LRP5 | Microglia [166], astrocytes [167], neurons [168] |
LRP6 | Microglia [166], astrocytes [169], neurons [170] |
TREM2 | Microglia [171], dendritic cells [172], astrocytes [173] |
TLR4 | Microglia [174], astrocytes [173], neurons [175] |
Results retrieved from human, animal and in vitro studies. () Other names by which the receptor is also known