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. 2022 Sep 24;17:62. doi: 10.1186/s13024-022-00566-4

Table 1.

Interacting receptors with apoE and CNS cell types in which they can be expressed

Receptors interacting with apoE CNS cell-type
SORLA (SORL1, LR11) Microglia [154], Neurons [155, 156]
VLDLR Astrocytes, microglia, oligodendrocytes, pyramidal neurons, neuroblasts, glioblasts, Cajal-Retzius cells [123]
ApoER2 (LRP8) Granule cells of dentate gyrus, piramidal cells [123]
LDLR Astrocytes, neurons, oligodendrocytes [157, 158]
LRP1 Neurons, astrocytes, microglia, [159, 160]
LRP2 (Megalin) Oligodendrocytes [161], astrocytes [162], neurons [163]
LRP4 (MEGF7) Astrocytes, oligodendrocytes, microglia [164], neurons [165]
LRP5 Microglia [166], astrocytes [167], neurons [168]
LRP6 Microglia [166], astrocytes [169], neurons [170]
TREM2 Microglia [171], dendritic cells [172], astrocytes [173]
TLR4 Microglia [174], astrocytes [173], neurons [175]

Results retrieved from human, animal and in vitro studies. () Other names by which the receptor is also known