Table 1.
Various MOF-based nanotherapeutics for cancer diagnosis
| Diagnostic agents | Active ingredient | MOFs | Light source | Applications | Refs. |
|---|---|---|---|---|---|
| Gd(BDC)1.5(H2O)2 | Gd3+ | Gd(BDC)1.5(H2O)2 | – | MRI | [43] |
| Gd-Ru | Gd3+ | Gd-Ru | – | MRI | [44] |
| Mn-NMOF | Mn2+ | Mn-IR825 | – | MRI | [45] |
| Mn-TCPP | Mn3+ | Mn-TCPP | – | MRI | [47] |
| MIL-88A | Fe3+ | MIL-88A | – | MRI | [49] |
|
MIL-100 MIL-101 |
MIL-100 MIL-101 |
– | |||
| Fe-MIL-100@PB | Fe3+ | Fe-MIL-100 | – | MRI | [50] |
| NS@MOF-ZD2 | Fe3+ | MIL-101-NH2 | – | MRI | [51] |
| FePt-MOFs-tLyp-1 | Fe3+ | MIL-101(Fe) | – | MRI/CT | [53] |
| Fe-MIL-53-NH2-FA-5-FAM/5-FU | Fe3+ | Fe-MIL-53 | – | MRI | [54] |
| Fe3O4@UiO-66 | Fe3O4 | UiO-66 | – | MRI | [55] |
| Fe3O4@IRMOF-3 | Fe3O4 | IRMOF-3 | – | MRI | [56] |
| Zr-UiO | Zr | Zr-UiO | X-ray | CT | [59] |
| Hf-UiO | Hf | Hf-UiO | |||
| UiO-PDT | Zr | UiO-66 | X-ray | CT | [60] |
| Mn/Hf-IR825@PDA-PEG |
Mn2+ Hf4+ |
Mn/Hf-IR825 | X-ray |
MRI CT |
[61] |
| Au@MIL-88(Fe) | Fe3+ | MIL-88(Fe) | X-ray | MRI, CT and PAI | [63] |
| 89Zr-UiO-66/Py − PGA-PEG-F3 | 89Zr | UiO-66 | X-ray | PET | [68] |
| 64Cu-ZIF-8@ DOX | 64Cu | ZIF-8 | X-ray | PET | [69] |
| Zr-NMOF | TCPP | Zr-TCPP | Visible light (530 nm) | Optical imaging | [73] |
| nano-Yb-PVDC-3 |
Yb3+ PVDC |
Yb-PVDC-3 | NIR | Optical imaging | [77] |
| H2L-MOF | H2L | H2L-MOF | NIR-I fluorescence (646 nm) | Optical imaging | [79] |
| MIL-53(Al)-NH2@RhB | RhB | MIL-53(Al)-NH2 | Fluorescent light (375 nm) | Optical imaging | [80] |
| PS@MOF-199 | TPAAQ | MOF-199 | White light (400–700 nm) | Optical imaging | [81] |
| cal-TPP@(DCA5-UiO-66) | Fluorescent pyrene group | UiO-66 | Fluorescent light | Optical imaging | [82] |
| UCNPs@MOF-DOX-AS1411 | UCNPs | MIL-100 (Fe) | NIR (980 nm) | Optical imaging | [83] |
| ZGGO@ZIF-8-DOX | PersL NPs | ZIF-8 | Fluorescent light | Optical imaging | [87] |
| BQ-MIL@cat-fMIL | BP Quantum dot (BQ) | MIL-101-NH2 | Fluorescent light | Optical imaging | [88] |
| MCH | Polydopamine modified hyaluronic acid | MIL-100 | NIR (808 nm) | PAI | [94] |
| (ZIF-8) derived carbon nanoparticles | – | ZIF-8 | NIR (808 nm) | PAI | [95] |
| Cu-THQNPs | tetrahydroxyanthraquinone (THQ) | Cu-THQNPs | NIR II (1000–1350 nm) | PAI | [96] |
| AuNR@- ZIF-8 | AuNR | ZIF-8 | NIR | PAI | [97] |
| UCNPs@MIL-101(Fe) |
Fe3+ UCNPs |
MIL-101(Fe) | Luminescence | MRI and UCL | [100] |
| MIL-100(Fe)@HA@ICG |
Fe3+ ICG |
MIL-100(Fe) | Luminescence | MRI, PAI and Optical imaging | [101] |
| UCNPs@ZIF-8 |
Ag2S Ag2Se |
ZIF-8 |
X-ray NIR (980 nm) |
CT, PAI and Optical imaging | [102] |