Table 2.
The involvement of the single gene in LC
| Gene | The involvement of the gene in LC | References |
|---|---|---|
| B3GAT2 | – | – |
| BCAR1 | B3GAT2 promotes the formation and immune evasion of CTCs in LUAD by triggering EMT via RAC1 signaling and up-regulating CD274 expression by shuttling BRD4-S into the nucleus | [52] |
| HOPX | ΜicroRNA-421 promotes the progression of NSCLC by targeting HOPX and regulating the Wnt/β-catenin signaling pathway | [53] |
| HOXD11 | – | – |
| MIR1203 | MIR1203 level is negatively regulated by LINC00632 to accelerate lymph node metastasis and distant metastasis of NSCLC | [54] |
| MYL9 | Low MYL9 expression may be relevant to the development and metastasis of NSCLC | [55] |
| SLC9A3R2 | – | – |
| SYT5 | – | – |
| VTRNA1-3 | – | – |
| HLF | Genetic deletion and methylation lead to down expression of HLF, thus accelerating anaerobic metabolism to promote the growth of NSCLC cells by activating NF-κB/p65 signaling through disrupting translocation of PPARα and PPARγ | [56] |