Figure 3.

Neutrophil metabolism and dysregulated IFN signaling are associated with severity and acuity

(A) Boxplots of NMF5 metagene score for healthy and COVID-19⁺ samples grouped by A_Max.

(B) Receiver operating characteristic (ROC) curve for performance of logistic regressions predicting COVID-19 severity on day 0. Significance of model improvement determined by likelihood ratio tests.

(C) ROC curve of performance of a LASSO model of COVID-19 severity on day 0 (STAR Methods) with median AUC curve across cross-validation repeats in red.

(D) Bar plot of inclusion frequency for each variable in the LASSO model.

(E) GSEA for genes DE between COVID-19⁺ patients with A_Max1 (death) or A_Max2 (intubation, survival).

(F) GSEA enrichment plots for gene sets with genes ranked by DE in (E).

(G) GSEA enrichment plots for NMF3 and NMF6 gene signatures with genes ranked by DE in (E).

See also Figure S3 and Table S3.