Fig. 1.

The sequence-based ODiNPred analysis predicts a significant amount of disorder in the distal N-termini of the human TRPV1, TRPV2 and TRPV3 channels. Regions with low predicted disorder propensities (shaded in light grey), as seen in particular for TRPV1 and TRPV2, could indicate the transient formation of structural order. The circles show the residue-specific Z-score (upper panel) and disorder probability (lower panel). A residue specific Z-score larger than 8 (solid line) indicates structural order while a Z-score below three (dashed line) predicts full disorder. Z-scores between three and eight reflect transient local structure propensity. The Z-score and disorder probability were calculated using the ODiNPred webserver (Dass et al. 2020)