Table 2:

Drug release and biodistribution properties of capsaicin sustained release drugs

Name of drug	Type of sustained release formulation	Composition of sustained release formulation	In Vitro drug release			In vivo biodistribution studies
			Drug release pattern	Cellular uptake of drug	Comparison of drug release pattern with free capsaicin/blank formulation	Models	Organ biodistribution	Comparison of drug release pattern with free capsaicin/ blank formulation
CAP-UREA-SDDDS	Solid State dispersion system	Urea scaffold	Approximately 38% of the drug cargo (capsaicin) was released within the first hour Approximately 100% of the capsaicin was released within 8 days	ND	CAP-UREA-SDDS released capsaicin more slowly than free capsaicin	ND	ND	ND
CAP-SOY-PL	Phospholipid complexes	Soyabean phospholipids	Approximately 60% of the capsaicin was released within 10 hours Approximately 100% of the drug was released at 30 hours	ND	CAP-SOY-PL released capsaicin more slowly than free capsaicin	ND	ND	ND
CAP-CUR-GLY-GAL-LIPO	Liposome	DSPE-PEG	Approximately 60% of the drug cargo (capsaicin) was released within 15 hours Approximately 60% of the drug 95% of the drug was released at 48 hours	Maximal uptake of liposomal drugs is at 4 hours in HepG2 cells At 4 hours the uptake of GLY-GAL-LIPO> GLY-LIPO=GAL-LIPO>blank-LIPO Maximal retention of liposomal drugs is at 12hours hours in HepG2 /LX2 co-cultured cells At 12 hours and 24 hours the retention of GLY-GAL-LIPO> GLY-LIPO=GAL-LIPO>blank-LIPO	Drug retention of GLY-, GAL-functionalized liposomes was greater than free capsaicin	B16/H22 tumor-bearing Balb/c mice	Most of the GLY-, GAL-functionalized liposomes were found in the liver. GLY-, GAL-functionalized liposomes were only localized to the H22 liver tumor. No liposomes were detected in the B16 melanoma tumor GLY-, GAL-functionalized liposomes showed deep penetration inside the solid H22 liver tumor	ND