Table 3:
Name of drug | Type of sustained release formulation | Targeting ligand | Drug cargo | Growth inhibitory activity in vitro | Is the in vitro growth inhibitory activity greater than free capsaicin | Anti-tumor activity in vivo | Is the in vivo growth inhibitory activity greater than free capsaicin | Mechanism of growth- inhibitory activity | Signaling mechanisms |
---|---|---|---|---|---|---|---|---|---|
CAP-UREA-SDDDS | Solid State dispersion system | None | Capsaicin | MCF-7 MDA-MB-231 |
Yes, in MCF-7 cells | ND | ND | ND | ND |
CAP-SOY-PL | Phospholipid complexes | None | Capsaicin | MCF-7 MDA-MB-231 |
Yes, in MDA-MB231 cells | ND | ND | ND | ND |
CAP-CUR-GLY-GAL-LIPO | Liposome | GLY, GAL | Capsaicin, Curcumin | HepG2. HepG2/LX2 co-cultured cells | Yes |
|
Yes |
|
|