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. 2022 Sep 23;30(6):14200–14211. doi: 10.1007/s11356-022-22949-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Effect of mountain with spa rehabilitation on platelet mitochondrial bioenergetics in patients with post-COVID-19 syndrome. Legend: ce: ROUTINE respiration of intact platelets; 1PM: complex I-linked LEAK (state 4) respiration with substrates (pyruvate + malate); 2D: complex I-linked OXPHOS (state 3) respiration capacity associated with CI-linked ATP production; 2D;c: The OXPHOS capacity after cytochrome c addition; 3U: The respiration after uncoupler FCCP titration represents CI-linked electron transfer (ET) capacity with substrates pyruvate+malate; 4G: ET capacity with substrates pyruvate+malate+glutamate; 5S: CI&CII-linked ET capacity with substrates pyruvate + malate + glutamate + succinate, (Doerrier et al. 2016; Gvozdjáková et al. 2019). The respiratory rates are marked according the steps in the SUIT protocol 1 (see Fig. 2). Control — the control group; MR1 — patients before mountain spa rehabilitation; MR2 — patients after mountain spa rehabilitation. CI — complex I pathway; CI&CII — complex I and complex II pathway; LEAK — the non-phosphorylating resting state of respiration; OXPHOS — the phosphorylating state of respiration; ET — the noncoupled state of respiration at optimum uncoupler concentration