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. 2022 Sep 12;13:903771. doi: 10.3389/fimmu.2022.903771

Table 6.

Top keywords of macrophage-derived cytokines and RA-related macrophage functions (occurrences> 60).

Rank Macrophage-derived cytokines RA-related macrophage functions
Keyword Occurrences Keyword Occurrences

  • 1

  • tumor-necrosis-factor (TNF-α)

  • 1786

  • cytokines

  • 825

  • 2

  • interferon-gamma (IFN-γ)

  • 288

  • activation

  • 819

  • 3

  • colony-stimulating factor (CSF)

  • 259

  • differentiation

  • 344

  • 4

  • interleukin-6 (IL-6)

  • 244

  • apoptosis

  • 229

  • 5

  • nitric oxide (NO)

  • 231

  • chemokines

  • 199

  • 6

  • chemokines

  • 199

  • cytokine production

  • 128

  • 7

  • growth-factor-beta (GF-β)

  • 170

  • innate immunity

  • 114

  • 8

  • migration inhibitory factor (MIF)

  • 165

  • oxidative stress

  • 114

  • 9

  • lipopolysaccharide (LPS)

  • 123

  • immune-response

  • 75

  • 10

  • endothelial growth-factor

  • 107

  • polarization

  • 72

  • 11

  • GM-CSF

  • 107

  • migration inhibitory factor

  • 70

  • 12

  • monocyte chemoattractant protein-1(MCP-1)

  • 100

  • proinflammatory cytokines

  • 68

  • 13

  • interleukin-1 (IL-1)

  • 94

  • metabolism

  • 65

  • 14

  • proinflammatory cytokines

  • 68

  • signal-transduction

  • 64

  • 15

  • cyclooxygenase-2 (COX-2)

  • 63

  • migration

  • 63