Table 1.

The incidence rate of cases of myocarditis/pericarditis by different COVID-19 mRNA vaccination programs based on total administered dose.

Manufacturer	Vaccination program		Total doses administered	Myocarditis		Pericarditis		Myopericarditis		In total
				Cases	Incidence rate*	Cases	Incidence rate*	Cases	Incidence rate*	Cases	Incidence rate*
Pfizer-BioNTech	Primary series
		Dose 1	151,453,547	189	1.25 (1.08-1.44)#	185	1.22 (1.05-1.41)#	33	0.22 (0.15-0.31)#	407	2.69 (2.43-2.96)#
		Dose 2	124,212,958	773	6.22 (5.79-6.68)	395	3.18 (2.87-3.51)	107	0.86 (0.71-1.04)	1,275	10.26 (9.71-10.84)
		In total	275,666,505	962	3.49 (3.27-3.72)	580	2.1 (1.94-2.28)	140	0.51 (0.43-0.60)	1,682	6.10 (5.81-6.40)
	Booster dose
		Dose 3	53,149,023	78	1.47 (1.16-1.83)#%	71	1.34 (1.04-1.69)#%	10	0.19 (0.09-0.35)#%	159	3.00 (2.55-3.49)#%
Moderna	Primary series
		Dose 1	92,443,636	181	1.96 (1.68-2.27)#	124	1.34 (1.12-1.60)#	26	0.28 (0.18-0.41)#	331	3.58 (3.21-3.99)#
		Dose 2	75,595,568	293	3.88 (3.45-4.35)	225	2.98 (2.60-3.40)	57	0.75 (0.57-0.98)	575	7.61 (7.00-8.25)
		In total	168,039,204	474	2.82 (2.57-3.09)	349	2.08 (1.87-2.31)	83	0.49 (0.39-0.61)	906	5.39 (5.05-5.75)
	Booster dose
		Dose 3	41,513,786	58	1.40 (1.06-1.81)#%	46	1.11 (0.81-1.48)#%	6	0.14 (0.05-0.31)#%	110	2.65 (2.18-3.19)#%
All mRNA	Primary series
		Dose 1	243,897,183	370	1.52 (1.37 - 1.68)#	309	1.27 (1.13 - 1.42)#	59	0.24 (0.18 - 0.31)#	738	3.03 (2.81-3.25)#
		Dose 2	199,808,526	1,066	5.34 (5.02 - 5.67)	620	3.10 (2.86 - 3.36)	164	0.82 (0.70 - 0.96)	1,850	9.26 (8.84-9.69)
		In total	443,705,709	1,436	3.24 (3.07 - 3.41)	929	2.09 (1.96 - 2.23)	223	0.50 (0.44 - 0.57)	2,588	5.83 (5.61-6.06)
	Booster dose
		Dose 3	94,662,809	136	1.44 (1.21 - 1.70)#%	117	1.24 (1.02 - 1.48)#%	16	0.17 (0.09 - 0.27)#%	269	2.84 (2.51-3.20)%#

*Defined as per million doses (95% confidence interval [95% CI]); ^% P < 0.05, compared with primary series; ^#P < 0.05, compared with dose 2.

mRNA, messenger RNA; COVID-19, coronavirus disease 2019.