Figure 3.

Significantly higher levels of PGE₂, 5-HETE, 15-HETE, 9-HODE and LTB₄ detected in patients with moderate–severe disease compared with healthy volunteers. Lipidomics obtained by mass spectrometry and liquid chromatography. pooled data presented as mean±SEM. One-way analysis of variance used for comparisons. Healthy=6 volunteers, mild= 9 patients, moderate–severe=15 patients. 5-HETE, 5-hydroxyeicosatetranoic acid; 15-HETE, 15-hydroxyeicosatetranoic acid; 9-HODE, 9-hydroxyoctadecadienoic acid; LTB₄, leukotriene B₄; PGE₂, prostaglandin E₂.