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(A) Bacterial phagocytosis and (B) killing. LXA4 significantly increased phagocytosis and killing of PAO1 by airway neutrophils isolated from the lung segments affected by Bx in mild, moderate and severe diseases. In unaffected segments, LXA4 only had an improvement in bacterial killing in patients with severe Bx only. Pooled data presented as mean±SEM. Paired t-tests used for all comparisons. Bx, bronchiectasis; LXA4, lipoxin A4; PAO1, Pseudomonas O1.
