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. Author manuscript; available in PMC: 2023 May 1.
Published in final edited form as: Genomics. 2022 Mar 26;114(3):110349. doi: 10.1016/j.ygeno.2022.110349

Figure 5. ceRNA network of neonate and child CPCs.

Figure 5.

a PCA plot of CPC coding and non-coding CPC RNAs (PC1, PC2, PC3) show clustering by patient age group.

b Volcano plot of differentially expressed non-coding RNAs between neonate and child CPCs. Thirty-six and 98 RNAs are upregulated in neonate and child cells, respectively.

c Fold-change values for each RNA in various categories. RNAs upregulated in child CPCs (purple), compared to neonate CPCs (yellow). N represents number of measured RNAs in each category.

d Schematic for ceRNA network construction: differentially expressed RNAs between neonate and child CPCs were matched in miRcode and miRTarBase by putative target sites.

e Full ceRNA network of differentially expressed RNAs (neonate vs. child CPCs) with 107 nodes and 144 edges.

f Reduced MCODE network of the most highly connected RNA nodes.