Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 12;14:973068. doi: 10.3389/fnagi.2022.973068

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Lu, Tang, Li, Huang, Dou, Zhang, Hu, Chang, Wong and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Inhibition of PKC attenuated deficits of autophagy and synapse in middle-aged wild-type mice. (A) Autophagy protein expressions without or with PKC inhibitor (BIMX) following laparotomy in the wild-type mice. (B) Spread of synaptic proteins, including PSD95 and synaptophysin, was observed using immunofluorescent staining in the cornu ammonis (CA) 3 hippocampal region after laparotomy. (C) Synaptic protein expressions in the cytosol and synaptosome in postoperative hippocampi without or with BIMX using Western blot analysis. (D) Activities of PKR with pharmacological inhibition of PKC in middle-aged wild-type mice after laparotomy. Wt, wild type; Ctrl, control; Lap, laparotomy. Data are presented as mean ± SEM and were analyzed using one-way ANOVA using Tukey's post hoc test, ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001.